A case study of primary testicular lymphoma：diagnosis and treatment strategies
10.3969/j.issn.1000-8179.2013.13.013
- VernacularTitle:1例原发睾丸淋巴瘤的临床特点与诊治分析
- Author:
Zheng SONG
;
Huaqing WANG
;
Zhengzi QIAN
;
Huilai ZHANG
;
Qiongli ZHAI
;
Xin YAO
;
Jianyu XIAO
;
Xiuyu SONG
;
Peiguo WANG
;
Yafei WANG
- Publication Type:Journal Article
- Keywords:
primary testicular lymphoma;
multi-modality treatment;
intrathecal chemotherapy
- From:
Chinese Journal of Clinical Oncology
2013;(13):799-803
- CountryChina
- Language:Chinese
-
Abstract:
Primary testicular lymphoma comprises 1% to 9% of testicular neoplasms and represents 1% to 2% of all non-Hodg-kin lymphomas. Histologically, the majority of the tumor consists of diffuse large B-cell non-Hodgkin lymphomas that are of intermedi-ate- or high-grade neoplasm. Clinically, the disease typically presents as a painless testicular swelling that develops over a span of weeks to months. B symptoms such as fever, weight loss, and anorexia are present in 25% to 41% of the patients. This tumor is an ag-gressive type, with frequent invasion of the epididymis, spermatic cord, and scrotum, as well as a marked tendency to relapse, especial-ly in the CNS. The treatment is mainly based on orchiectomy (mostly in stages ⅠE and ⅡE) regardless of its association with prophy-lactic irradiation of the scrotum and administration of intrathecal chemotherapy, cyclophosphamide, doxorubicin, vincristine, and pred-nisone regimen chemotherapy plus rituximab (R-CHOP) (stages ⅢE and ⅣE) and radiotherapy. The multi-modality treatment marked-ly improved progression-free and overall survival. We introduce as reference one case that received a multidisciplinary comprehensive discussion in the Department Lymphoma, Tianjin Medical University Cancer Hospital.
