Relationship between Serum Leptin Levels and Atherosclerosis in Type 2 Diabetes Patients.
- Author:
Min Gyu KONG
1
;
Seok Chun YEUM
;
Jin Woo CHOO
;
Hyeong Kyu PARK
Author Information
1. Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. hkpark@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Leptin;
Atherosclerosis;
Type 2 diabetes mellitus
- MeSH:
Atherosclerosis;
Cardiovascular Diseases;
Carotid Intima-Media Thickness;
Cholesterol;
Cholesterol, LDL;
Diabetes Mellitus, Type 2;
Humans;
Kidney Failure, Chronic;
Leptin;
Lipoprotein(a);
Lipoproteins;
Multivariate Analysis;
Pulse Wave Analysis;
Risk Factors
- From:Soonchunhyang Medical Science
2012;18(1):38-42
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Many studies have suggested that leptin is a possible cause of atherosclerosis and is proposed as a cardiovascular risk factor in obese patients. Several studies have shown that serum leptin is associated with pulse wave velocity (PWV) and carotid intima-media thickness (IMT). But the relevance of serum leptin levels for predicting incident cardiovascular disease is less clear. In this study, we investigated the relationship between serum leptin levels and aortic PWV, carotid IMT in type 2 diabetes (T2DM) patients. METHODS: Patients with end-stage renal disease or advanced atherosclerosis, systemic infection were excluded. A total of 116 patients (60 male/56 female; age, 59+/-14 years) were included. Serum leptin levels, aortic PWV and carotid IMT were measured. RESULTS: Aortic PWV was significantly associated with age (r=0.28, P<0.005). Carotid IMT was significantly related to age (r=0.46, P<0.001), low density lipoprotein (LDL) cholesterol (r=0.22, P<0.05), lipoprotein (a) (r=0.23, P<0.05) and estimated glomerular filteration rate (r=-0.348, P<0.01). There was no correlation between leptin and aortic PWV or carotid IMT. In multivariate analyses, aortic PWV was associated with age (P=0.007). Carotid IMT was significantly related to age (P<0.001), LDL cholesterol (P=0.01). CONCLUSION: Serum leptin was not associated with aortic PWV or carotid IMT in T2DM patients.
