The influence of T cell subsets and natural killer cell on cytokine induced killer therapy for partial advanced non-small cell lung cancer patients
10.3760/cma.j.issn.1673-4904.2013.20.006
- VernacularTitle:细胞因子激活的杀伤细胞对局部晚期非小细胞肺癌同步放化疗患者T淋巴细胞亚群及自然杀伤细胞的影响
- Author:
Qiumin YANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Killer cells;
T-lymphocyte subsets
- From:
Chinese Journal of Postgraduates of Medicine
2013;(20):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of T cell subsets and natural killer cell ofcytokine induced killer (CIK) therapy for partial advanced non-small cell lung cancer patients.Methods Sixty-one patients with partial advanced non-small cell lung cancer were randomly divided into treatment group and control group by sortition method.In treatment group,31 patients received three dimensional conformal radiation therapy and chemotherapy,then received CIK treatment.In control group,30 patients received three dimensional conformal radiation therapy and chemotherapy.Results In treatment group,CD3+,CD4+,CD4+/CD8+ and CD16+ CD56+ after treatment were significantly higher than before treatment (0.7125 ± 0.0154 vs.0.6374 ± 0.0325,0.3921 ± 0.0461 vs.0.3217 ± 0.0287,0.0178 ± 0.0179 vs.0.0102 ± 0.0093,0.1855 ± 0.0321 vs.0.1224 ± 0.0177),CD8+ after treatment was significantly lower than before treatment (0.2209 ± 0.0257 vs.0.3147 ± 0.0307),there was significant difference (P ＜ 0.05).In control group,there were no significant difference in CD3+,CD4+,CD8+,CD4+/CD8+ and CD16+ CD56+ between after treatment and before treatment (0.6218 ± 0.0040 vs.0.6325 ± 0.0114,0.3311 ± 0.0278 vs.0.3347 ± 0.0209,0.3265 ± 0.0257 vs.0.3316 ± 0.0178,0.0101 ± 0.0108 vs.0.0101 ± 0.0117,0.1327 ± 0.0298 vs.0.1479 ± 0.0354,P ＞ 0.05).The side effects in the treatment group and control group showed no significant difference (P ＞0.05).Conclusion CIK therapy can improve immune function in patients with partial advanced non-small cell lung cancer.
