Expression and clinical significance of FoxM1 and Cep55 protein in basal-like breast carcinoma
10.3760/cma.j.issn.1673-4904.2013.20.003
- VernacularTitle:FoxM1、Cep55蛋白在基底细胞样型乳腺癌中的表达及临床意义
- Author:
Qiushuang MA
;
Jinku ZHANG
;
Bingjuan ZHOU
;
Wenming ZHAO
;
Yafei ZHAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
FoxM1 protein;
Cep55 protein
- From:
Chinese Journal of Postgraduates of Medicine
2013;(20):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of FoxM1 and Cep55 protein in basal-like breast carcinoma (BLBC).Methods The expression of FoxM1 and Cep55 protein in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue were detected by immunohistochemistry.Their relationship with the clinical pathological factors was analyzed.Results The positive rate of FoxM1 protein in BLBC,non-BLBC and normal adjacent breast tissue was 77.3％ (51/66),60.0％(42/70) and 13.6％(9/66),Cep55 protein was 74.2％(49/66),57.1％(40/70) and 16.7％(11/66),respectively.BLBC and non-BLBC tissue were higher than normal adjacent breast tissue,and BLBC tissue was higher than non-BLBC,there was significant difference (P ＜0.05).In BLBC tissue,the positive expression of FoxM1 and Cep55 protein correlated with lymph nodes metastasis and TNM staging (P ＜0.05),while did not correlate with age,menopause,tumor size (P ＞ 0.05).There was direct correlation between the positive expression of FoxM1 and Cep55 protein (r =0.259,P ＜ 0.05).Conclusion FoxM1 and Cep55 protein may play an important role in the carcinogenesis and development of BLBC,and both of them have the synergistic effect.
