Molecular markers for prognosis of gastric cancer
10.3760/cma.j.issn.1673-422X.2013.06.018
- VernacularTitle:胃癌预后分子标志物
- Author:
Caiyan LI
;
Kangsheng GU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Biological markers;
Prognosis
- From:
Journal of International Oncology
2013;(6):456-459
- CountryChina
- Language:Chinese
-
Abstract:
A variety of molecular markers are related to the prognosis of gastric cancer,such as the the loss expression of AT rich interactive domain 1A (ARID1A),the overexpression of CD133 and survivin are releated to the incidence and poor prognosis of gastric cancer; leptin,CD44 and microRNA (miRNA) are releated to the invasion and metastasis of gastric cancer; the low expression of secreted protein acidic and rich in cysteine (SPARC) contributes to the angiogenesis of gastric cancer,but the relationship between SPARC and prognosis needs further study; the expression and gene polymorphism of excision repair cross-complementing 1 (ERCC1) may be useful for choice of medication in the treatment of gastric cancer.
