Comparison of efficacy and safety of treatment for low pulmonary embolism severity index outpatient versus inpatient with acute pulmonary embolism
10.3760/cma.j.issn.1673-4904.2013.19.007
- VernacularTitle:低肺栓塞严重程度指数急性肺栓塞患者住院及非住院治疗的疗效及安全性比较
- Author:
Zhonghua CHEN
;
Dinghong YU
;
Mansheng LIU
- Publication Type:Journal Article
- Keywords:
Pulmonary embolism;
Anticoagulants;
Deinstitutionalization;
Pulmonary embolism severity index;
Self-management
- From:
Chinese Journal of Postgraduates of Medicine
2013;(19):19-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of self-management anticoagulation treatment for low pulmonary embolism severity index (PESI) outpatient with acute pulmonary embolism (APE).Methods Sixty-eight patients with APE of PESI grade Ⅰ-Ⅱ were divide into inpatient group and outpatient group with 34 cases each by random digits table.All the patients were treated with low molecular heparin followed by oral anticoagulation,and self-management was used in outpatient group.The efficacy was observed within 14 days and 3 months.The efficacy outcome included recurrent venous thromboembolism (VTE),standardization time of international normalized ratio (INR),VTE-related emergency department visit times,bleeding events and total mortality.Results There were 2 cases(5.9％,2/34) in inpatient group and 1 case (2.9％,1/34) in outpatient group with recurrent VTE,and there was no statistical significance between two groups (P ＞ 0.05).Standardization time of INR in inpatient group [(8.5 ± 2.9) d] was shorter than that in outpatient group [(16.1 ± 4.4) d],and there was significant difference (P＜ 0.01).There was no significant difference in the VTE-related emergency department visit times between two groups (P ＞ 0.05).There was 1 case with major bleeding and 1 death respectively in outpatient group.Conclusion It is effective and safe to give early self-management anticoagulation treatment to APE patients with PESI grade Ⅰ-Ⅱ,which could shorten time spending in hospital and release burden both physically and mentally.
