Inlfuence of transport protein gene polymorphisms on the effects and toxicity of high-dose methotrexate in child-hood acute lymphoblastic leukemia

VernacularTitle:转运蛋白基因多态性对儿童急性淋巴细胞白血病大剂量甲氨蝶呤治疗的影响
Author: Aidong LU ; Leping ZHANG ; Bin WANG ; Yueping JIA ; Yingxi ZUO ; Jun WU ; Yamei HUANGSHAN ; Guanhua HU ; Guilan LIU
Publication Type:Journal Article
Keywords: multidrug resistance gene 1; reduced folate carrier; genetic polymorphism; acute lymphoblastic leuke-mia; methotrexate
From: Journal of Clinical Pediatrics 2013;(8):733-736
CountryChina
Language:Chinese
Abstract: Objectives To investigate the inlfuence of polymorphisms of SLC19A1 80G>A, MDR1 exon26C>T and MDR1 exon21G>T/A on curative effect and adverse reaction of high-dose methotrexate in patients with acute lymphoblastic leukemia. Methods MALDI-TOF-MS technique was used to detect the polymorphisms of SLC19A1 80G>A, MDR1 exon 26C>T and MDR1 exon21G>T/A in 108 patients with acute lymphoblastic leukemia (ALL). The relationship of genetic polymorphism, survival rate and toxicity was analyzed. Results The 36-month event-free survival was not related to any polymorphisms of MDR1 and SLC19A1. Patients with mutant types of MDR1 exon26C>T and MDR1 exon21G>T/A showed a much higher MTX plasma levels at 24 hours and higher incidence of hepatic injury (P<0.05). Conclusions The genetic polymorphism of MDR1 exon26>T, MDR1 exon21G>T/A has a large inlfuence on hepatic toxicity and plasma concentra-tions of MTX.