The changes of serum IL-17 in children with Kawasaki disease
10.3969/j.issn.1000-3606.2013.08.011
- VernacularTitle:川崎病患儿血清白介素-17的变化
- Author:
Yunyan LI
;
Ling WU
;
Tianrui MA
;
Yuanling CHEN
;
Yazhen DI
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
serum;
interleukin-17;
child
- From:
Journal of Clinical Pediatrics
2013;(8):741-743
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the change of interleukin-17 (IL-17) in Kawasaki disease (KD). Methods Fourty KD pediatric patients, among them 12 patients with echocardiographic abnormalities in acute phase, 25 age-matched non-KD patients were enrolled. The level of serum IL-17 was measured by enzyme linked immunosorbent assay in acute and convalescent phase of KD patients and non-KD patients. At the same time, C-reactive protein (CRP), globulin, albumin were detected. Results In acute phase of KD patients, the level of serum IL-17 were signiifcantly higher than that in convalescent phase of KD patients and non-KD patients (P<0.05). The level of serum IL-17 was no signiifcant differences in convalescent phase of KD patients and non-KD patients (P>0.05). In acute phase of KD patients with echocardiography abnormalities, the level of serum IL-17 was signiifcantly higher than that with non-echocardiography abnormalities (P<0.05). The level of serum IL-17 in acute phase of KD patients were positively correlated with CRP and globulin (r=0.750, 0.750, P<0.05), and negatively correlated with albumin (r=-0.779, P<0.05). Conclusions IL-17 may be involved in KD immune pathogenesis. Serum IL-17 is one of the activity index of KD, which associ-ated with cardiovascular damages.
