The role of reactive oxygen species in the hyperdynamic circulation of cirrhotic portal hypertension
10.3760/cma.j.issn.1007-8118.2013.04.023
- VernacularTitle:活性氧在肝硬化门静脉高压症高动力循环中的作用
- Author:
Wei CHEN
;
Zhiyong WU
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hyperdynamic circulation;
Reactive oxygen species
- From:
Chinese Journal of Hepatobiliary Surgery
2013;(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is involved in cirrhotic portal hypertension and a close relationship exists between oxidative stress and hyperdynamic circulation.This article elaborates on the function of various reactive oxygen species (e.g.,superoxide anion and hydrogen peroxide) and corresponding anti-oxidants (e.g.,NAD(P) H oxidase inhibitor,the scavengers of superoxide anion,hydrogen peroxide,and vitamin C or E) on the occurrence and development of hyperdynamic circulation in cirrhotic portal hypertension.We observed that the level of reactive oxygen species in cirrhotic portal hypertension was elevated over normal.The potential clinical value is that inhibition or removal of these reactive oxygen species can relieve hyperdynamic circulation and reduce complications for cirrhotic portal hypertension.
