Immunosuppression mechanism of MDSCs and regulatory T cells in inflammation and tumor microenvironment

VernacularTitle:髓源性抑制细胞和调节性T细胞在感染和肿瘤微环境中的免疫抑制机制
Author: Jinquan ZHAO ; Jiansong WANG ; Hui ZHAN
Publication Type:Journal Article
Keywords: Immunosuppression; Inflammation; Neoplasms; T-lymphocytes,regulator; Myeloidderived suppressor cells
From: Journal of International Oncology 2013;(6):428-431
CountryChina
Language:Chinese
Abstract: Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are important inhibitory immune cells.Research finds that MDSCs and Tregs increase in a large number under the conditions of inflammation,infection and tumor and they are able to suppress the immunity system and promote tumorigenesis and metastasis through multiple mechanisms.Finding the causes resulting in the increase of MDSCs and Tregs in tumor microenvironment and the eliminating methods have become new focuses in the field of antitumor immunotherapy.