Peroxisome proliferator-activated receptor gamma and epithelial-mesenchymal transition in cancer

VernacularTitle:PPARγ及上皮-间质转化与肿瘤的关系
Author: Chao GAO ; Xiangying FENG
Publication Type:Journal Article
Keywords: PPAR gamma; Neoplasms; Smad protein; E-cadherin
From: Journal of International Oncology 2013;(6):425-428
CountryChina
Language:Chinese
Abstract: Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells,which is one of the reasons for treatment failure.Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells.Recent researches show that activation of PPARγplays a role in the occurrence and development of EMT by regulating the E-cadherin,Smad complex and body microenvironment.Therefore,in-depth research for the relationship among PPARγ,EMT and cancer is expected to provide a new direction for tumor treatment.