The role and relation of STAT3 and epithelial-mesenchymal transition in tumor cells
10.3760/cma.j.issn.1673-422X.2013.06.007
- VernacularTitle:STAT3与上皮-间质转化在肿瘤细胞中的作用及其关系
- Author:
Xu LI
;
Xiaoping ZOU
- Publication Type:Journal Article
- Keywords:
Transcription factors;
Neoplasms;
Neoplasm metastasis;
Neoplasm invasiveness
- From:
Journal of International Oncology
2013;(6):422-424
- CountryChina
- Language:Chinese
-
Abstract:
STAT3 can be activated by various cytokines and participate in the process of tumor cells proliferation,angiogenesis,invasion and chemotherapy resistance.Epithelial-mesenchymal transition (EMT)also plays an important role in the process of tumor invasion and metastasis and chemotherapy resistance.Studies have shown that STAT3 can regulate the process of EMT so as to change the invasion and metastasis abilities of tumor cells,and to enhance their ability of chemotherapy resistance.Discussion of the role and relation of STAT3 and EMT in tumor cells will be helpful to provide reliable theory for tumor molecular targeted therapy.
