Research of hypoxia-inducible factor in tumor angiogenesis
10.3760/cma.j.issn.1673-422X.2013.06.005
- VernacularTitle:缺氧诱导因子促进肿瘤血管生成的研究
- Author:
Wenwen SUI
;
Weidong ZHANG
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor;
Vascular endothelial growth factors;
Neovascularization,pathologic
- From:
Journal of International Oncology
2013;(6):416-418
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor (HIF) is an important transcriptional factor,which plays crucial role in response to hypoxia.HIF is highly expressed in many human cancers,and it is closely related to tumor angiogenesis.HIF promotes tumor growth,invasion and metastasis via up-regulating vascular endothelial growth factor gene and starting associated angiogenesis.With the in-depth study of HIF regulation of tumor angiogenesis mechanism,HIF is expected to become an important target for anti-angiogenesis therapy.
