Multidrug resistance mediated by ABCG2
10.3760/cma.j.issn.1673-422X.2013.06.001
- VernacularTitle:ABCG2介导的肿瘤多药耐药
- Author:
Fei SHEN
;
Baoan CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Drug resistance,multiple;
ABCG2 protein,human
- From:
Journal of International Oncology
2013;(6):403-406
- CountryChina
- Language:Chinese
-
Abstract:
ABCG2 is a member of the ATP-binding cassette (ABC) transporter family.The overexpression of ABCG2 is identified as one of the important mechanisms that limiting cellular accumulation of various compounds.With regard to its broad substrate spectrum including various anticancer drugs and environmental carcinogens,the function of ABCG2 is associated with multidrug resistance (MDR) and tumor development.ABCG2 as a target site to reverse MDR has been widely concered.
