Evaluation of hemocompatibility of a new biopolymer material for bioabsorbable stents used for children with vascular stenosis in vitro
10.3969/j.issn.1000-3606.2010.09.001
- VernacularTitle:小儿生物可降解血管支架新型材料血液相容性评价
- Author:
Lijiao ZHAO
;
Kun SUN
;
Qimao FENG
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
hemocompatibility;
bioabsorbable;
intravascular stents;
in vitro
- From:
Journal of Clinical Pediatrics
2010;(9):801-806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the hemocompatibility of polydioxanone(PDO)bioabsorbable stents.Methods Whole blood clotting time,prothrombin time(PT),activated partial thromboplastin time(APTT),platelet adhesion and hemolysis were used to evaluate the hemocompatibility of PDO bioabsorbable stents,and the results were compared with those of 316L stainless stents which are widely used clinically.Results The anticoagulant property of PDO bioabsorbable stents was similar to that of 316L stainless stents.Both PDO bioabsorbable and 316L stainless stents were not prone to activate blood coagulation factors.Compared with 316L stainless stents,PDO bioabsorbable stents had weaker platelet adhesion and activation.Hemolysis ratios of two groups were less than 5%.Conclusions PDO bioabsorbable stents had good hemocompatibility in vitro.
