Effect of Tongsaimai Tablet on experimental atherosclerosis in rats
- VernacularTitle:通塞脉片对大鼠实验性动脉粥样硬化模型血管内皮细胞的影响
- Author:
Yuwei YANG
;
Chen HU
;
Huimin BIAN
;
Xiaoming DAI
- Publication Type:Journal Article
- Keywords:
Tongsaimai Tablet(TSM);
atherosclerosis;
circulating endothelial cell;
AngⅡ;
rat
- From:
Chinese Traditional Patent Medicine
2010;(3):371-374
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of TSM tablet on rat' s atherosclerotic model' s endothelial cell and explore the mechanism of it.METHODS:Fifty Wistar rats were randomly assigned into five groups:control group,model group,Simvastatin group,TSM high group,TSM low group.All groups were fed with high fat diet and vitamin D_3 except for control group to set up atherosclerosis model.After 12 weeks we detected circle endothelial cell,angiotensin Ⅱ and electron microscopy morphology of arteries.RESULTS:Level of circulating enthelia cell(CEC)and Ang Ⅱ in model rats were significantly higher.TSM can reduce level of the CEC and Ang Ⅱ.Model group rat' s artery endothelial cells were severely damaged under electron microscopy;rat's artery endothelial cells in TSM group were basically intact and its internal elastic membrane was unbroken on it thickness was even,without significant lesion.CONCLUSION:TSM by reducing the number of CEC,the level of Ang Ⅱ used for experimental atherosclerotic endothelial cell in rats has the protective effect.
