Expression and significance of IGF-IR and PKC in laryngeal squamous cell carcinoma
10.3969/j.issn.1001-1781.2010.04.004
- VernacularTitle:胰岛素样生长因子-Ⅰ受体和蛋白激酶C在喉鳞状细胞癌中的表达及意义
- Author:
Jie LIU
;
Song PAN
;
Yuanhong ZHOU
;
Zhihua YU
;
Lisi LIU
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor-I receptor;
protein kinase C;
laryngeal neoplasms;
carcinoma,squamous cell
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;(4):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of IGF-IR and PKC and their clinical significance in laryngeal squamous cell carcinoma(LSCC).Method:The expression of IGF-IR and PKC protein were detected by immunohistochemistry and Western blot in 60 cases of LSCC, 25 cases of adjacent non-tumorous laryngeal epithelium and 10 cases of normal laryngeal epithelium.Result:The positive rate of IGF-IR and PKC expression in LSCC were significantly higher than that in normal laryngeal epithelium and adjacent non-tumorous laryngeal epithelium(P<0.05). IGF-IR positive expression were increased more in cases with stage Ⅲ-Ⅳ, cervical lymph node metastasis and well differentiation than that in cases with stageⅠ-Ⅱ, non-lymph node metastasis and poor/mediate differentiation, respectively(P<0.05).The positive rate of PKC in LSCC were correlated with clinical stage and cervical lymph node metastasis.There was a correlation between the expression of IGF-IR and PKC in LSCC.Conclusion:The overexpression of IGF-IR and PKC in the laryngeal carcinoma may play an important role in the carcinogenesis and development of LSCC. It is suggested that detecting the expression of IGF-IR and PKC can be used for early diagnosis and treatment of LSCC.
