A prospective study on cigarette smoking and liver cancer risk: a Meta-analysis
10.3781/j.issn.1000-7431.2010.03.015
- VernacularTitle:吸烟与肝癌前瞻性研究的荟萃分析
- Author:
Wanshui YANG
;
Jing GAO
;
Shan GAO
;
Jing WANG
;
Yongbing XIANG
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Smoking;
Prospective studies;
Meta-analysis;
R software
- From:
Tumor
2010;(3):247-252
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between tobacco smoking and liver cancer risk.Methods:Cohort studies of cigarette smoking and risk of liver cancer were identified by searching MEDLINE and CBM databases from January 1989 to September 2009. Results from individual studies were combined synthetically by Meta analysis using R software and Meta package. Results:A total of 19 articles were included in our analysis. The cohort totally included 3 023 558 followed-up persons and 9 525 cases of liver cancer patients. The pooled relative risk (RR) of liver cancer was 1.49 (95%CI: 1.17-1.92) for smokers compared with non-smokers. The results showed a statistically moderate association between tobacco smoking and the risk of liver cancer. Subgroup analysis indicated that the pooled RRs for smoking were 1.53(95%CI : 1.29-1.83)for male smokers and 1.70(95%CI :1.17-2.48)for female smokers, respectively.Conclusion:Tobacco smoking is a risk factor for liver cancer in both males and females.
