An in vivo study on tetrandrine as a synergist to econazole against Trichophyton mentagrophytes
10.3969/j.issn.1002-2694.2010.03.008
- VernacularTitle:汉防己甲素对益康唑抗须癣毛癣菌活性增效作用的体内实验研究
- Author:
Ding ZHANG
;
Hong ZHANG
;
Hairui LI
;
Shuixiu LI
;
Jianping SHI
- Publication Type:Journal Article
- Keywords:
tetrandrine;
synergistic effect;
econazole;
dermatophytosis
- From:
Chinese Journal of Zoonoses
2010;(3):222-225
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the synergistic effect of tetrandrine (TET) to the anti-Trichophyton mentagrophytes activity of econazole (ECZ) in vivo,animal model of dermatophytosis in guinea pig was established by inoculating Trichophyton mentagrophytes conidia.These 40 infected animals were divided into 4 groups randomly and from Day 5 after inoculation,they were treated with the following formulations once per day for successive 14 days: 1% econazole and 1% tetrandrine compound cream (1%ECZ+1%TET group),1% econazole cream (1%ECZ group),1%TET cream (1%TET group) and matrix cream (matrix group).The alterations in the skin lesions and the pathological changes were observed.From the 4~(th) day of drugs applying,the tendency of lesion score about 1%ECZ+1%TET group continued to decline.On the 14~(th) day of drugs applying,the lesion score decreased to 0.75.There was a similarity between 1%ECZ+1%TET group and 1%ECZ group in tendency of lesion score,but more reduction was appeared in 1%ECZ+1%TET group than in 1%ECZ group (mean 0.75 VS 2.00) with obviously statistical difference (P=0.037).The culture results of skin sections and the pathological changes in 1%ECZ+1%TET group were less than those of other 3 groups.It's predicted that there is a synergistic effect of tetrandrine to the anti-Trichophyton mentagrophytes of econazole in animal model of dermatophytosis in guinea pig.
