Genomic analyses of dengue viruses and origins of dengue strains from China

VernacularTitle:登革病毒的基因组分析及中国登革毒株的来源
Author: Yongjun ZHANG ; Chaohui ZHOU ; Meng HUANG ; Jinzhang WANG ; Wei CHEN
Publication Type:Journal Article
Keywords: dengue virus; genome; sequence analysis
From: Chinese Journal of Zoonoses 2012;(6):515-521
CountryChina
Language:Chinese
Abstract: Dengue is the most wide-spread arthropod-borne viral disease of humans in the tropic and sub-tropic regions.In this study,genomic sequences of more than 3 000 dengue viruses available in the GenBank were aligned and analyzed by sero type.According to phylogenetic trees generated by the minimum evolution method of MEGA5.0,dengue viruses were divided into 4-6 genotypes within the four serotypes,respectively.Meanwhile,it was indicated that the distribution of most genotypes was associated with geographic origins of dengue viruses.Probable origins for most of the 39 strains from China with genomic sequences were deduced from relevant ancestral strains in the context of ME trees.These results revealed that the genotype distribution of dengue viruses was geographic origin-specific at genomic level,and that diverse introduction sources were attributed to dengue outbreaks in China.