Variation of serum ferrin, folic acid and vitamin B_(12) levels in patients with acute promyelocytic leukemia
10.3781/j.issn.1000-7431.2010.03.013
- VernacularTitle:血清铁蛋白、叶酸和维生素B_(12)水平的变化在急性早幼粒细胞白血病中的意义
- Author:
Yan LIU
;
Xiping LIU
;
Xiangshan CAO
;
Xiaobao XIE
;
Weiying GU
;
Bin YANG
;
Bai HE
;
Haiqian LI
;
Xinyu QIAN
- Publication Type:Journal Article
- Keywords:
Leukemia,promyelocytic,acute;
Ferritin;
Folic acid;
Vitamin B12
- From:
Tumor
2010;(3):239-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the dynamic variation of serum ferritin (SF), folic acid, and vitamin B_(12) levels in patients with acute promyelocytic leukemia (APL) at different disease stages. Methods:Serum SF, folic acid and vitamin B_(12) levels were successively tested in thirty-six patients with primary APL every 1 to 3 months by using chemiluminescence analysis. Five different disease stages were selected as dynamic observation time points: first diagnosed, first complete remission (CR1), six months after CR1, relapsed stage,and CR1 for three years. Results:There were 75.0%(27/36)of patients with abnormal high levels of SF, 77.8% (28/36)of patients with abnormal low levels of folic acid, and 100%(36/36)of patients with increased vitamin B_(12) levels in first diagnosed stage. The number of patients with abnormal variations of SF, folic acid and vitamin B_(12) level was decreased in CR1 stage compared with those in first diagnosed stage (SF: P<0.05;folic acid and vitamin B_(12): P<0.01). The serum SF, folic acid and vitamin B_(12) levels tended to recover step by step with chemotherapy. At six months after CR1 the three parameters of most patients recovered to normal levels. APL was relapsed in 4 patients after 1-year CR. Both SF and vitamin B_(12) levels were increased and the folic acid level was decreased compared with those before replase, but the difference had no significance (P>0.05). The serum SF, folic acid and vitamin B_(12) levels were in normal ranges in the patients who had 3-year CR. Conclusion:The serum SF, folic acid and vitamin B_(12) levels had dynamic variation in APL course. Increase in serum SF and vitamin B_(12) as well as decrease in folic acid are related with the active degree of APL and its tumor load.
