Research progress of the function of high mobility group A2 protein in malignant tumors
10.3781/j.issn.1000-7431.2010.03.017
- VernacularTitle:恶性肿瘤中高迁移率族蛋白A2的功能研究进展
- Author:
Lang ZHA
;
Ziwei WANG
- Publication Type:Journal Article
- Keywords:
Oncogenes;
Tumor stem cells;
HMGA2 protein
- From:
Tumor
2010;(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
The high mobility group A2 (HMGA2) is a non-histone chromatin protein. It has no transcriptional activity of itself but could alter chromatin structure to regulate the transcription of other genes. HMGA2 gene is weakly expressed or does not express in normal tissues. The expression of HMGA2 is up-regulated during embryogenesis and malignant neoplasias. In several malignant tumors, HMGA2 is used as a diagnostic molecular marker or an independent prognostic indicator. Furthermore, HMGA2 not only elicits epithelial-mesenchymal transition but also maintains the differentiation potential and self-regeneration capability of stem cells. It plays an important role in initiation, proliferation, and metastasis of malignant neoplasias.
