Naturally occurring antibodies to streptococcal C5a peptidase from group B streptococcus(SCPB)in neonates
10.3969/j.issn.1000-3606.2010.03.009
- VernacularTitle:新生儿血清 B 族链球菌表面蛋白 SCPB 抗体检测
- Author:
Haidong WANG
;
Aihua WANG
;
Liqin YIN
;
Haixia WANG
;
Xuzhuang SHEN
;
Yonghong YANG
;
Baoquan ZHU
- Publication Type:Journal Article
- Keywords:
group B streptococcus;
newborn;
antibody
- From:
Journal of Clinical Pediatrics
2010;(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the antibodies of streptococcal C5a peptidase from group B streptococcus(SCPB)in neonates,demonstrate the existence of SCPB antibody in pregnant women after natural group B streptococcus(GBS)infection,and provide clinical evidence for prevention of GBS infection. Methods Sera were collected from 107 neonates(80 term infants and 27 premature infant)between February 2007 and December 2007. The antibodies of SCPB were detected using ELISA method,and cultures of GBS were done simultaneously. Results 21(19.6%)newborns were found to be SCPB antibody positive(including 20 term infants and 1 premature infant),the difference of positive ratio between term and premature infant was significant(25% and 3.7%,respectively). Conclusions This study indicated that pregnant women could produce SCPB antibody by immune response,and transmitted it to the infants through the placenta. Further study is needed to clarify the effect of SCPB antibody in expectant mother and newborn with GBS infection.
