Inhibition effects of Fuerkang Injection and its ingredients on SMMC-7721 and NB4 cell lines
- VernacularTitle:复尔康注射液及拆方制剂对SMMC-7721和NB4细胞株的抑制作用
- Author:
Wenyu FENG
;
Bing HE
;
Liming ZHOU
- Publication Type:Journal Article
- Keywords:
Fuerkang Injection;
decomposed recipes preparations;
SMMC-7721;
NB4;
cell inhibitory rate
- From:
Chinese Traditional Patent Medicine
2010;(2):189-191
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the inhibitiory effects of Fuerkang Injection (sweet worm wood oil, glycyrrhetate and Vitamin A acetate). and its ingredients on SMMC-7721 and NB4 cell lines, in order to understand its antitumour spectrum and reasonability of its composition. METHODS: SMMC-7721 and NB4 cell lines were treated with Fuerkang Injection and its ingredients under the same concentration for 48 h, adfiamycin was used as standard com-parison,inhibitiory effect on growth of two cell lines was detected by MTT method. RESULTS: At 1.260 μg/mL, the inhibition rate of Fuerkang Injection and its decomposed recipes preparations 1,2,3 to SMMC-7721 cell lines were 54.78%, 55.49%, 53.18%, 53.79%, hemi-inhibitory concentration IC_(50) were 0.415,0.376,0.715 and 0.636 μg/mL,respectively. The inhibition rate of NB4 cell lines were 88.6% ,82.5% ,77.9% and 76.9% ,hemi-inhibitory concentration IC_(50) were 0.091,0.108 1,0.084 and 0.120 μg/mL. CONCLUSION: Fuerkang Injection and its ingredients have significant inhibitory action on SMMC-7721 and NB4 cell lines,each component herb in the compound preparation has synergetic effects.
