Drug delivery of sinomenine hydrochloride floating and pulsatile release tablet
- VernacularTitle:盐酸青藤碱漂浮型脉冲释放片的释药机理研究
- Author:
Yaling WU
;
Yanna GENG
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
sinomenine hydrochloride;
floating and pulsatile release tablets;
in vitro drug delivery
- From:
Chinese Traditional Patent Medicine
2010;(2):209-213
- CountryChina
- Language:Chinese
-
Abstract:
AIM : To prepare a phase-specific drug delivery system withfloating and pulsatile release of sinome-nine hydrochloride and evaluate in vitro drug release behavior. METHODS: The floating and pulsatile-release of coat-core tablets were prepared by press-coated technics. The effects of factors influencing release characteristic of the drug were investigated by dissolution test, and to elucidate the mechanism of drug releaseof the tablets with erosion and water-uptake test. RESULTS: The tablets had typical floating and pulsatile release properties with a lag time rapid release. The lag-time was shortened with the increase of expansion ratio of tablet core and rotation speed of stirrer. The lag-time was prolonged with the increase of pH and ionic strength of dissolution media.CONCLUSION: The tablet could float and rapidly release drug at the predetermined time.
