Dermal toxicology and absorption of Triptolide Compound Cream
- VernacularTitle:雷公藤内酯醇复方乳膏剂皮肤毒理及其透皮吸收性能研究
- Author:
Zhenghai LONG
;
Dengming WEI
;
Jibin DU
- Publication Type:Journal Article
- Keywords:
Triptolide;
Compound Cream;
toxicology;
pemeability
- From:
Chinese Traditional Patent Medicine
2010;(2):213-218
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream. METHODS: 2% azone+1% volatile oil of twig from Camellia. oleifera was used as permeation enhancer to prepare Triptolide Compound Cream. Acute dermal toxicity, irritation a sensitization test on mouse were carried out. And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity, irritation or hypersensitive effects. 2% azone+1% volatile oil had more powerful enhancement effects, after 12 h, amont of drug delivery/unit area Q/( μg/cm~2) and absorption percentage Q% of tfiptolide and meloxican in the preparation reached a platea conventration. The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin, and there is a good dermal absorption.
