Pathogenesis of immune dysfunction in septic and immunoregulation therapy
10.3969/j.issn.1000-3606.2010.01.004
- VernacularTitle:脓毒症免疫功能紊乱及免疫调节治疗
- Author:
Chengrong LI
- Publication Type:Journal Article
- Keywords:
sepsis;
Toll-like receptor;
innate/adaptive immune responses;
Treg;
Th17;
immuno-regulation therapy
- From:
Journal of Clinical Pediatrics
2010;(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of immune dysfunction in septic has been summarized in this review.Innate immune response toward pathogens is initiated by pattem recognition receptor (PRR) such as Toll-like receptor (TLR) .Inflammatory cytokines derived from innate immune response not only cause inflammatory response.but also trigger adaptive immune responses through inducing the differentiation of naive T cell into Th1, Th2, CD4~+CD25~+Foxp3~+ regulatory T cells (Treg), and Th17 cells. Adaptive immune response might suppress or enhance inflammatory response.Abnormal activation of innate/adaptive immune responses may coexist in sepsis, resulting in immune dysfunction.Logical and adequate approach of immunoregulation therapy to sepsis may be to suppress PRR persistent activation by eliminating endogenous or exogenous ligands, as well as to avoid excessive inhibition of immune responses to infection.
