Expression of CyclinD1 protein in nephroblastoma
10.3969/j.issn.1000-3606.2010.01.021
- VernacularTitle:肾母细胞瘤中CyclinD1蛋白的表达及其意义
- Author:
Hongfang WU
;
Baomin FU
;
Xiaoming CHEN
;
Zhongmin WANG
- Publication Type:Journal Article
- Keywords:
CyclinD1;
p53;
nephroblastoma;
immunohistochemistry
- From:
Journal of Clinical Pediatrics
2010;(1):73-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CyelinD1 protein in nephroblastoma.Methods The tissue microarray were made in 28 cases of nephroblastoma and 19 cases of renal tissue adjacent to tumor.The expression of CyclinD1 and p53 proteins were detected by immunohistochemistry.Results The positive rate of the expression of CyclinD1 and p53 protein was significantly different between nephroblastoma and renal tissue adjacent to tumor (P < 0.05).The positive rate of the expression of CyclinD1 and p53 protein was significantly different in different degree of differentiation of nephroblastoma (P < 0.05).The expression of CyclinD1 and p53 protein was positively correlated (P < 0.05).Conclusions The CyclinD1 and p53 might be used as the marks for estimating the degree of differentiation of nephroblastoma.The over-expression of CyclinD1 and the mutation of p53 might play the vital role in nephroblastoma.
