Drug release of Compound Salvia Multi-component released Double-layer Tablet
- VernacularTitle:复方丹参多元释药双层片的体外释药研究
- Author:
Changchun PENG
;
Qin ZHENG
;
Pengyi HU
;
Junjie PAN
;
Chunhua LAI
;
Ming YANG
- Publication Type:Journal Article
- Keywords:
compound salvia;
multi-component release;
double-layer tablets;
in vitro release
- From:
Chinese Traditional Patent Medicine
2010;(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish the drug release method of Compound Salvia Multi-component released Doublelayer Tablet and investigate its in vitro drug release behavior and the influencing factors of the drug release rate.METHODS: The method of evaluating in vitro release rate of double-layer tablet was established with salvianolic acid B and gindenoside Rg_1 as index,The influencing factors of the release of rapid release layer and sustained release layer of double-layer tablet and their in vitro drug release behavior were studied.RESULTS: The rapid release layer showed the quick releasing effect; The drug release curve of sustained release layer accorded with Ritger-Peppas equation; artificial gastric juice had significant effect on the release curve of gindenoside Rg_1 which in double-layer tablets,but had no significant effect on the release curve of salvianolic acid B.CONCLUSION: The evaluation of in vitro release rate of Compound Salvia Multi-component released Double-layer Tablet shows good properties of fast and sustained release and clinic application is achieved.
