Common bacteria for lower respiratory tract infection in children and its current status of antibiotic resistance
10.3969/j.issn.1000-3606.2010.02.002
- VernacularTitle:儿童下呼吸道感染常见细菌病原分布及耐药现状
- Author:
Changchong LI
;
Li LIN
- Publication Type:Journal Article
- Keywords:
lower respiratory tract infection;
bacteria;
children
- From:
Journal of Clinical Pediatrics
2010;(2):106-111
- CountryChina
- Language:Chinese
-
Abstract:
Lower respiratory tract infection (LRTI), particularly pneumonia, is a leading killer of children. Bacteria are the main pathogen of LRTI in children of developing countries. Streptococcus pneumoniae is the most important pathogen causing LRTI. An increase in the incidence of invasive pneumococcal disease (IPD) caused by non-vaccine serotypes (NVTs) (serotype replacement) has been observed since the introduction of the seven-valent pneumococeal conjugate vaccine (PCV7), and the increasing antibiotic resistance to NVTs is of particular concerns. Genetic and microbiological studies have revealed that community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) is associated with a novel genetic profile and phenotype that distinguish it from hospital-acquired (HA) MRSA. There are obviously different antibiotic resistance between CA-MRSA and HA-MRSA. Gram-negative bacilli are still the chief pathogens in HA-LRTI. The common pathogens between CA-LRTI and HA-LRTI are different, but have overlaps. To understand the distribution and current status of antibiotic resistance to the common bacteria of LRTI in children is very important to guide clinical rational drug use.
