Expression and significance of COX-2 and S-100positive dendritic cell in laryngeal carcinoma
10.3969/j.issn.1001-1781.2010.03.002
- VernacularTitle:环氧化酶-2和S-100~+树突状细胞在喉癌中的表达及意义
- Author:
Gang QIN
;
Zhuoping LIANG
;
Ling YU
;
Zuyao CHEN
;
Wenjun LIU
;
Wanrong LI
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
cyclooxygenase-2;
dendritic cell;
carcinoma,squamous cell;
immunohistochemical
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;(3):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of cyclooxygenase-2(COX-2) and S-100 positive dendritic cell in laryngeal carcinoma tissue and their clinical significance.Method:Sixty-five samples of laryngeal carcinoma and thirty-four biopsies of adjacent noncancerous tissue were obtained. Immunohistochemical technique(SP method) was used to detect the expression of COX-2 and S-100 positive dendritic cell, and the relationship of their expression with clinical pathological parameters and prognosis was analyzed.Result:The rates of COX-2 expression were 63.08%(41/65)and 14.70%(5/34)in laryngeal carcinoma and control group, respectively. The difference was significant(P＜0.05).The positive expression of COX-2 was correlated with T and clinical stage in laryngeal carcinoma(all P＜0.05).The rates of S-100 positive dendritic cell expression were 61.54%(40/65)and 0 in laryngeal carcinoma and control group, respectively. The difference was significant(P＜0.05).S-100 positive dendritic cells showed significant differences between early and late clinical stage and lymph node metastasis (all P＜0.05).Kaplan-Meier survival analysis showed that patients with positive expression of COX-2 and S-100 positive dendritic cell had worse disease-free and overall survival(P＜0.05).Cox regression analysis showed that S-100 positive dendritic cell was indicated as an independent prognostic factor for survival(P＜0.05).Conclusion:COX-2 and S-100 positive dendritic cell are highly expressed in laryngeal carcinoma tissue. It suggests that the expression of COX-2 and S-100 positive dendritic cell is related to the process of carcinogenesis and may be the important indicators in laryngeal carcinoma for prognosis.
