Research on apoptosis changes of tensor veli palatini in patients with obstructive sleep apnea-hypopnea syndrome

VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征上气道开大肌凋亡现象研究
Author: Hongxun GONG ; Xianming CHEN ; Xian ZHANG ; Fengfang LIU
Publication Type:Journal Article
Keywords: sleep apnea-hypopnea syndrome,obstructive; apoptosis-related proteins; apoptosis
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2010;(3):108-111
CountryChina
Language:Chinese
Abstract: Objective:To explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of Bax, Bcl-2 in tensor veli palatini in patients with OSAHS.Method:The expression of Bax and Bcl-2 were detected in tensor veli palatini in 30 cases with OSAHS and 10 cases chronic tonsillitis without OSAHS by immunohistochemistry and image analytical system, and the results were analyzed.Result:①The expression levels of Bax in the OSAHS group increased significantly compared to control group(P<0.05), but there were no significant differences of Bcl-2 expression between two groups, the ratio of Bax/Bcl-2 increased significantly(P<0.05). ②There were positive correlations between AHI and the expression levels of Bax(r=0.697,P<0.01) respectively in the test group.Conclusion:The results indicate that apoptosis occurred in tensor veli palatini in patients with OSAHS, and the more severity of OSAHS , the more apoptosis.