Expression and relationship of EBV LMP1, COX-2 and VEGF-C in nasopharyngeal carcinoma

VernacularTitle:EB病毒潜伏膜蛋白-1和环氧合酶-2及血管内皮生长因子C在鼻咽癌中的表达及其关系
Author: Xiang YI ; Anzhou TANG ; Ying QIN ; Wensheng WEN ; Weimin ZHAO
Publication Type:Journal Article
Keywords: nasopharyngeal neoplasms; Epstein-Barr virus; latent membrane protein 1; cyclooxygenase-2; vascular endothelial growth factor C
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2010;(3):126-128
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the expression of vascular endothelial growth factor C(VEGF-C),Epstein-Barr virus(EBV) latent membrane protein 1(LMP1),cyclooxygenase-2 (COX-2) in nasopharyngeal carcinoma(NPC).Method:LMP1, COX-2 and VEGF-C were detects by immunohistochemical staining for 57 case NPC tissue.Result:The positives rates of LMP1,COX-2 and VEGF-C detected by immunohistochemical staining were 49.1%(28/57), 75.4%(43/57)and 59.6%(34/57), respectively. The expression of LMP1, COX-2 and VEGF-C were correlated to each1 other in NPC(P<0.05).Conclusion:LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression, may contribute to lymph metastasis and develop NPC.