Notch signaling pathway and glioma stem cell niche
10.3760/cma.j.issn.1673-422X.2013.06.011
- VernacularTitle:Notch信号通路与脑胶质瘤干细胞的niche
- Author:
Caihou LIN
;
Zongqing ZHENG
;
Xianxin QIU
;
Zhixiong LIN
- Publication Type:Journal Article
- Keywords:
Tumor stem cells;
Receptors,Notch;
Endothelial cells
- From:
Journal of International Oncology
2013;(6):434-436
- CountryChina
- Language:Chinese
-
Abstract:
A small fraction of tumor stem cells exist in glioma and play a key role in the tumorigenesis and propagation of glioma.They have a close relationship with their niche that offers structural and functional support.In glioma niche,vascular endothelial cells can provide Notch ligands for cancer stem cells to activate Notch signaling pathway and contact with other signaling pathways,maintaining the tumor stem cell self-renewal and increasing resistance of brain tumor stem cells to radiotherapy.Therefore,Notch signaling pathway is considered to be a new therapeutic target of glioma.
