Analysis of prevalence and antibiotic resistance of Haemophilus influenzae in children with acute respiratory tract infection in Suzhou 2006 -2007
10.3969/j.issn.1000-3606.2010.02.008
- VernacularTitle:2006-2007年苏州地区儿童呼吸道感染流感嗜血杆菌分布及耐药性分析
- Author:
Junhua WU
;
Wei JI
;
Yunzhen TAO
;
Lu HUANG
;
Yali LUO
- Publication Type:Journal Article
- Keywords:
children;
respiratory tract infections;
Haemophilus influenzoe;
antibiotic resistance
- From:
Journal of Clinical Pediatrics
2010;(2):131-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence, clinical characteristics and antibiotic resistance of Haemophilus influenzae (HI) in children with acute respiratory tract infection in Suzhou. Methods Data of sputum culture of 3 167 hospitalized childhood patients with acute respiratory tract infection from January 2006 to December 2007 were collected. The incidence of positive HI and the rate of resistance to different antibiotics were calculated and beta-lactamases of the strains were detected. Results About 4.4% of total 3 167 eases were infected with HI. The infection rate was related with season and sex, more frequent between February and June, more common in boys than girls. Children younger than three years old were likely to be infected by HI, eompared with other age groups. The beta-lactamase positive rate of HI was 31.4%. The resistance rates to ampicillin, SMZ + TMP, chloramphenicol, cefaclor, ceftazidime, tetracycline and ampicillin/sulbactam were 29.6% ～ 31.9%, 66.2% -73.9%, 19.7% ～ 15.9%, 2.8% ～ 14.5%, 2.8% ～0、 28.2% ～ 2.9% and 4.2% ～ 1.4% respectively. Isolates resistance to cefuroxime、 ceftriaxone、 imipenem、azithromycin and ciprofloxacin were not found. Conclusions The infection of HI in children with actue respiratory tract infection is closely related with season and sex in Suzhou. Children younger than three years old are at high risk. The beta-lactamase positive rate of HI was high and increased rapidly. Resistance rate to azithromycin, SMZ + TMP and chloramphenicol was high, some isolates were resistant to the second, third generation of cephalosporin. Monitoring the antibiotic resistance of H! should be emphasized.
