The study of long term effects on the young infected by Toxoplasma gordii during mother's pregnancy
10.3969/j.issn.1000-3606.2010.02.017
- VernacularTitle:对宫内感染弓形虫出生子代远期发育研究
- Author:
Wenying YUAN
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
infection;
middle-school students;
learning disorder;
memory disorder;
long-term effect
- From:
Journal of Clinical Pediatrics
2010;(2):164-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the long term effects of Toxoplasma gondii infection during pregnancy on memory and learning ability of her child and provide therapeutic strategy. Methods Middle-school students selected according to their mother's pregnant record of Toxoplasma gondii IgM, CAg were divided into three groups: healthy group (negative Toxoplasma gondii IgM, CAg in both mother's blood and umbilical cord blood), non infected group (positive in mother's blood, but negative in umbilical cord blood), infected group (positive in both mother's blood and umbilical cord blood). Infected group was subdivided into treated group (with special training) and untreated group. All objects wereevaluated their memory and learning ability with Mini-Mental State Examination (MMSE) , Tower of Hanoi (TOH-1-TOH-d-TOH-s-TOH-2) and Wisconsin Card Sorting Test (WCST-1-WCST-d-WCST-s-WCST-2). Results The scores in items about calculation, recall and total of MMSE were significantly lower in untreated group than that in non infected group (P < 0.05). The scores of TOH and WCST in infected group was significantly different from uninfected group (P < 0.05). The scores of WCST were significantly improved in treated group (P < 0.05) after training, however, have no difference in the scores of TOH between treated group and untreated group (P > 0.05). Conclusions Toxoplasma gondii infection during pregnancy damages the infected children's mental development. Early cognitive rehabilitation is very important for the infected children.
