Dynamic changes of INF-γ and IL-4 in the peripheral blood of mouse infected with Mycoplasma suis
10.3969/j.issn.1002-2694.2010.02.008
- VernacularTitle:小鼠感染猪附红细胞体后外周血INF-γ、IL-4的动态变化
- Author:
Lixian SONG
;
Yanbin ZHOU
;
Caifeng BA
- Publication Type:Journal Article
- Keywords:
Mycoplasma suis;
mouse model;
interleukin-4;
interferon-γ
- From:
Chinese Journal of Zoonoses
2010;(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
The changes in the levels of IFN-γ and IL-4 in peripheral blood of mice infected with Mycoplasma suis were investigated in the present study, in which BALB/c mice were infected with Mycoplasma suis and the levels of IFN-γ and IL-4 in peripheral blood of mice were determined by means of ELISA assay 3, 5 and 7 days after infection. The results showed that the lower level of IFN-γ and higher level of IL-4 could be demonstrated 3 and 5 days after infection in comparison with those of the control groups respectively(P<0.05, P<0.01), but there was no significant difference in the levels of IFN-γ and IL-4 after 7 days of infection (P>0.05) . It is evident from this result that determination of the levels of IFN-γ and IL-4 in peripheral blood of mice may constitute an additional sero-diagnostic index to infection with M.suis and provide the experimental data for the studies in the serology and immunology of this infection.
