Gene polymorphisms predict efficacy and toxicity of chemotherapy for colorectal cancer
10.3781/j.issn.1000-7431.2010.02.017
- VernacularTitle:基因多态性预测结直肠癌化疗效果和不良反应
- Author:
Jiaying HUANG
;
Wen ZHANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Polymorphism,genetic;
Polymorphism,single nucleotide;
Drug therapy;
Prognosis
- From:
Tumor
2010;(2):164-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The efficacy and toxicity of anticancer drugs differ in different tumor patients. It could not meet the requirements of optimization of tumor treatment if only under the guidance of clinical and pathologic characteristics. More and more attention is focused on individualized therapy based on individual gene profiles. It has been identified that gene polymorphisms are responsible for different outcomes of individuals. Gene polymorphisms, including sequence polymorphism and single nucleotide polymorphism, will decrease the clinical efficacy of chemotherapeutic drugs or increase adverse reactions by influencing the expression or activity of the corresponding proteins. In recent years several gene polymorphisms related to drug metabolism, transportation, or inactivation may affect the outcomes of chemotherapy and the frequency of adverse reactions. Identification of the polymorphism genes is important for individual therapy for tumor patients.
