Relationship between expression of Syk,VEGF-C and lymph node metastasis in breast carcinoma
10.3969/j.issn.1001-7399.2010.01.004
- VernacularTitle:乳腺癌中Syk、VEGF-C表达与淋巴结转移的关系
- Author:
Liang LI
;
Shizhang HUANG
;
Huiqiu ZHANG
;
Yajie ZHANG
- Publication Type:Journal Article
- Keywords:
breast neoplams;
syk;
VEGF-C;
lymph node metastasis;
lymphangiogenesis
- From:
Chinese Journal of Clinical and Experimental Pathology
2010;(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relationship between the expression of Syk,VEGF-C and lymph node metastasis in breast carcinoma.Methods Immunohistochemical EnVision and SP methods were used to detect the expression of Syk,NFκB(p65)and VEGF-C in 55 cases of breast carcinoma.Results The positive rates of Syk, VEGF-C and NFκB(p65)in 55 cases of breast carcinoma were 50.9%,56.4% and 81.8%,respectively.Lower positive rate of Syk was obtained in the group of positive lymph-node metastasis than that in the group of non-lymph-node metastasis (P<0.05);Higher positive rate of VEGF-C was obtained in the group of positive lymph-node metastasis than that in the group of non-lymph-node metastasis (P<0.05);But no significant differences was found in p65(P>0.75).Higher positive rate of p65 nuclear expression was obtained in the group of positive lymph-node metastasis than that in the group of non-lymph-node metastasis (P＜0.025).The expression of Syk was negatively associated with VEGF-C (r=-0.620,P=0.000);the nuclear expression of p65 was associated with the low expression of Syk(r=0.448,P=0.002)and the high expression of VEGF-C (r=0.310,P=0.036).Conclusions In breast carcinoma, Syk may downregulate the expression of VEGF-C by inhibiting the activation of NFκB, which suppresses the lymph node metastasis of the cancer.
