IMP3 expression and its relationship with clinicopathological characteristics in breast carcinoma
10.3969/j.issn.1001-7399.2010.01.005
- VernacularTitle:乳腺癌中IMP3表达及其与临床病理特征的关系
- Author:
Peng SU
;
Qifeng YANG
;
Zhiqiang ZHOU
;
Yan WANG
;
Wenjun LIU
;
Qinghui ZHANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
IMP3;
tissue array;
triple negative
- From:
Chinese Journal of Clinical and Experimental Pathology
2010;(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of IMP3 and its relationship with clinicopathological characteristics in breast cancer.Methods By the tissue microarray technique and immunohistochemical EliVision two-step method, expression of IMP3 was detected in 214 cases of breast carcinoma.Results Of the 214 breast cancer cases,IMP3 expression was seen in 31(14.49%). IMP3 expression in the tumor cells was positively correlated with histological grade (P=0.005), proliferative index labeled by Ki-67 (P=0.033) and triple negative phenotype (P<0.001). There were no associations between IMP3 expression and age, tumor size, lymph node metastases, pTNM stage or p53 expression (P>0.05).Conclusions Expression of IMP3 is correlated with higher histologic grade, higher proliferative activity and triple negative breast carcinoma.Our findings indicate that IMP3 plays an important role in breast cancer progression, and IMP3 could be an adjuvant diagnostic marker in triple negative breast carcinoma.
