Clinical significance of ostenopontin and minkine protein expression in infiltrating breast carcinoma
10.3969/j.issn.1001-7399.2010.01.006
- VernacularTitle:浸润性乳腺癌中OPN和MK蛋白的表达及临床意义
- Author:
Yanjiao HU
;
Shupeng ZHAO
;
Fengjie QI
- Publication Type:Journal Article
- Keywords:
infiltrating breast carcinoma;
osteopontin;
MK;
immunohistochemisty;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2010;(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To detect the expression of osteopontin(OPN) and minkine(MK) protein in paraffin-embedded samples obtained from patients with infiltrating breast carcinoma and to analyze the relationships between their expression and clinical feature and prognosis in order to provide valuable biomarkers for the treatment and prognosis of infiltrating breast carcinoma.Methods The expression of OPN and MK was measured in 90 infiltrating breast cancer tissues and 30 hyperplastic disease of the breast by immunohistochemical PV-9000 two-step method.Results Immunohistochemical results showed that the positive rates of OPN and MK in infiltrating breast carcinoma were 71.11% (64/90) and 78.89 (71/90), respectivelyy, which were significantly higher than that in hyperplastic diseases of breast [30.00% (9/30) and 46.67% (14/30)](P<0.05);the expression of OPN was significantly correlated with tumor size, axillary lymph node metastasis,recurrence of tumor and the expression of p185(P<0.05),but not with the TNM stage,histological type,grade,and ER and PR status(P>0.05).The expression of MK was significantly correlated with tumor size,axillary lymph node metastasis,recurrence of tumor , the expression of p185 and TNM stage(P<0.05), but not with histological type, grade,and ER and PR status(P>0.05).There was a significantly positive relationship between OPN and MK expression (r=0.274,P=0.009). TTP and OS in patients with OPN and MK positive expression were shorter than those with OPN and MK negative expression (P<0.05).Conclusions OPN and MK′s expression may correlate with the progression of breast cancer.OPN and MK′s detection may provide a theoretical basis for the diagnosis and treatment of infiltrating breast carcinoma.
