Alveolar soft part sarcoma: a clinicopathological analysis of 21 cases
10.3969/j.issn.1001-7399.2010.01.016
- VernacularTitle:21例腺泡状软组织肉瘤的临床病理分析
- Author:
Mei ZHOU
;
Gang ZHAO
;
Feng ZHAO
;
Jingyin LI
- Publication Type:Journal Article
- Keywords:
alveolar soft part sarcoma;
pathological features
- From:
Chinese Journal of Clinical and Experimental Pathology
2010;(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinical and pathological features and differential diagnosis of alveolar soft part sarcoma (ASPS).Methods The clinical data were retrospectively analyzed in 21 cases of ASPS. Histopathological and immunohistochemical changes of the tumors were also observed in the paraffin-embedded tissue samples.Results In 21 cases, 11 were male and 10 females. Ages of the patients ranged from 4 to 56 years old,with mean 25.9 years old.The lesions were mainly located in the deep soft tissues of legs.Microscopically,tumor cells with granular cytoplasm arranged in alveolar or solid structures,and were separated by sinusoidal vessels. There existed crystals in the cytoplasm of tumor cells after PAS staining.Immunohistochemically,10 cases were positive for MyoD1, 4 positive for desmin,9 positive for S-100,11 positive for NSE, and 11 positive for Vim. All of ASPS were negative for AE1/AE3,CK, EMA, SMA, MSA and Syn.Conclusions ASPS is a rare malignant neoplasm in adolescents and young adults. It is prone to early hematogenous metastases and a high recurrence rate after conservative surgical excision. Therefore, the prognosis of ASPS is poor. Careful analysis of the clinicopathological features and immunohistochemisitry will be helpful to reach an accurate diagnosis.
