The expressions and their of vascular endothelial growth factor and extracellular matrix in non-small cell lung cancer
10.3781/j.issn.1000-7431.2010.02.011
- VernacularTitle:血管内皮生长因子与细胞外基质在非小细胞肺癌中的表达及其临床意义
- Author:
Jian NI
;
Yan XU
;
Bing LU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Vascular endothelial growth factors;
Extracellular matrix;
Immunohistochemistry
- From:
Tumor
2010;(2):138-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions and their clinical significance of vascular endothelial growth factor (VEGF) and extracellular matrix (ECM) components in non-small cell lung cancer (NSCLC). Methods:Expressions of VEGF and ECM components (fibronectin, FN and collagen Ⅳ, cⅣ) in 50 cases of NSCLC tissues and 20 cases of normal lung tissues were detected by immunohistological analysis. Their relationship with clinical features of NSCLC and the correlation of expression of VEGF and Fn and cⅣ were analyzed.Results:The positive expression rates of VEGF, Fn, and cⅣ were 96%, 78%, and 50% in NSCLC tissues. The expressions of VEGF and Fn were significantly higher than those in normal lung tissues (P<0.05). The expression of Fn and over-expression of VEGF were associated with lymph node metastasis (r=1.00, P<0.001). The survival rate of patients with over-expression of VEGF was greatly lower than that with weak expression of VEGF (P=0.022). The survival rate of Fn-negative patients was markedly higher than that of Fn-positive patients (P=0.046). Conclusion:VEGF and ECM component Fn were highly expressed in NSCLC, which correlated with lymph node metastasis and survival rate. Expression of ECM and VEGF had positive correlations, suggesting that ECM might be one of the anti-angiogenesis targets for tumor therapy.
