The expression of insulin-like growth factor-binding protein related protein 1 (IGFBP-rP1) in children with acute leukemia and its clinical significance
10.3781/j.issn.1000-7431.2010.01.011
- VernacularTitle:胰岛素样生长因子结合蛋白相关蛋白1基因在儿童急性白血病中的表达及临床意义
- Author:
Xiaorui MAN
;
Shaoyan HU
;
Jiannong CEN
;
Zixing CHEN
;
Hailong HE
;
Jie LI
;
Yihuan CHAI
- Publication Type:Journal Article
- Keywords:
Leukemia;
Gene,IGFBP-rP1;
Child
- From:
Tumor
2010;(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of insulin-like growth factor-binding protein related protein 1(IGFBP-rP1) gene in children with acute leukemia and its potential significance. Methods:Real-time fluorescence quantitative PCR (RFQ-PCR) method was used for detecting IGFBP-rP1 mRNA expression in bone marrow (BM) cells of 168 children with acute leukemia. The results were compared with those of 30 non-leukemia children in control group. Meanwhile the relationship between IGFBP-rP1 expression level and clinical prognosis was analyzed according to clinical prognostic factors of children acute leukemia. Results:Expression level of IGFBP-rP1 in initial acute leukemia children was significantly higher than that of non leukemia children (P<0.01). It was higher in acute myeloid leukemia (AML) than in acute lymphoblastic leukemia (ALL)(P =0.013). The transcription level of IGFBP-rP1 mRNA in patients who had complete remission (CR) were lowest, which was nearly the same as non-leukemia childish patients. It increased again when leukemia relapsed, which was significantly higher than that in CR. However, as far as ALL was concerned, IGFBP-rP1 expression levels had no significant difference between newly-diagnosed, complete remission, and recurrent groups.Conclusion:IGFBP-rP1 may be involved in the initiation and development of childish leukemia. It has the potential to become a new target for AML treatment.
