Advances in radionuclide molecular imaging of pancreatic β-cells
10.3760/cma.j.issn.2095-2848.2013.01.022
- VernacularTitle:核素分子影像技术在胰岛β细胞显像中的研究进展
- Author:
Ye LIU
;
Wei FANG
;
Tianpei HONG
;
Zhaohui ZHU
;
Haining WANG
- Publication Type:Journal Article
- Keywords:
Islets of langerhans;
Radionuclide imaging;
Molecular Imaging;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;(1):74-78
- CountryChina
- Language:Chinese
-
Abstract:
In both type 1 and type 2 diabetes mellitus,β-cell mass (BCM) is lost.Various treatments are developed to restore or reconstruct BCM.The development of non-invasive methods to quantify BCM in vivo offers the potential for early detection of β-cell dysfunction prior to the clinical onset of diabetes.PET imaging with radioligands that directly target the pancreatic β-cells appears promising.The ability to determine the BCM has been investigated in several targets and their corresponding radiotracers,including radiolabeled receptor ligands,antibodies,metabolites and reporter genes.Therefore,we summarize the recent progress in radionuclide molecular imaging of pancreatic β-cells.
