Clinical efficacy of 90Sr-90Y applicator combined with propranolol treatment on large infantile cutaneous hemangiomas
10.3760/cma.j.issn.2095-2848.2013.01.013
- VernacularTitle:90Sr-90Y敷贴联合普萘洛尔治疗婴幼儿大面积皮肤血管瘤的临床观察
- Author:
Zhenwu TANG
;
Jianghe HUANG
;
Jiahua TANG
- Publication Type:Journal Article
- Keywords:
Hemangioma;
Infant;
Propranolol;
Brachytherapy;
Strontium radioisotopes;
Yttrium radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of 90Sr-90Y applicator combined with propranolol (inderal) treatment for infants with large areas of cutaneous hemangiomas.Methods Thirty-nine infants with large areas of cutaneous hemangiomas were randomly divided into two groups:study group (n =18) treated with 90Sr-90Y applicator in conjunction with propranolol,and control group (n =21) treated by 90Sr-90Y applicator only.The results of curative effects between the two groups were analyzed using rank sum test and x2 test.Results The cure rate,remission rate and effective rate for the study group were 44.4％(8/18),55.6 ％ (10/18) and 100.0％ (18/18),respectively,and the corresponding rates for the control group were 14.3％ (3/21),52.4％ (11/21) and 66.7％ (14/21),respectively.The effective rate in the study group was significantly higher than that in the control group (Z =-2.861,P ＜ 0.05).The adverse reaction rates in the study and control groups were 66.7％ (12/18) and 19.0％ (4/21 ;x2 =9.084,P ＜0.05),respectively.Conclusion Combined propranolol with 90Sr-90Y treatment for large infantile hemangiomas is clinically effective,but its side effects should be closely monitored.
