CT guided embedding of 125I by puncturing tissue through the cutis in patients with metastatic lung tumors
10.3760/cma.j.issn.2095-2848.2013.01.012
- VernacularTitle:CT引导下经皮穿刺125I粒子植入治疗肺转移癌的临床应用
- Author:
Chi CAO
;
Long CHENG
;
Dahai YU
;
Guojun LI
;
Ning CUI
;
Haijiang WU
- Publication Type:Journal Article
- Keywords:
Neoplasm metastasis;
Lung;
Brachytherapy;
Iodine radioisotopes;
Tomography,X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;(1):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application and safety of treatment of percutaneous radioactive 125I seed implantation treatment in lung metastases under CT guidance.Methods Twenty-seven lung metastatic malignancy cases (67 nodules) were studied.Eighteen cases (46 nodules) were hepatic cancer,4 cases (9 nodules) were prostate cancer,and 5 cases (12 nodules) were breast carcinoma.Diameters of lung nodules ranged from 0.5 cm to 4.0 cm with an average diameter of 2.1 cm.125I seeds were embedded under CT guidance,using 2 to 33 particles/nodule with an activity of 18.5 to 29.6 MBq/grain for each particle.Tumor matched peripheral dose was 90-120 Gy.Postoperative validation and quality evaluation followed.Results Four months later,24 nodules showed CR,30 showed PR,5 showed NC and 8 showed PD.The total effective rate was 80.6％ (54/67).In the course of treatment,11 patients had pneumothorax,3 had heavy lung compression and 4 had hemoptysis.All conditions were improved by pleural puncture or under close follow-up observation.Conclusion 125I seed implantation is an effective and safe technique in treatment of metastatic lung tumors under CT guidance.
