The differential expression of vascular endothelial growth factor and its receptor subtypes in myocardial infarction rats
10.3760/cma.j.issn.1008-1372.2013.02.016
- VernacularTitle:血管内皮生长因子及其受体各亚型在心肌梗死大鼠体内的差异性表达
- Author:
Qinjun TAO
;
Xuefeng JIN
;
Si SHI
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factors/biosynthesis;
Vascular endothelial growth factor receptor-1/biosynthesis;
Vascular endothelial growth factor receptor-2/biosynthesis;
Vascular endothelial growth factor receptor-3/biosynthesis;
Myocardial infarction/meta
- From:
Journal of Chinese Physician
2013;(2):200-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expressions of the vascular endothelial growth factor (VEGF) family and their receptors in cardiac repair/remodeling after myocardial infarction (MI).Methods The infarcted rat heart model were constructed,real time PCR (RT-PCR) and Western blots (WB) were used.Results Compared to the normal myocardium,VEGF-A was significantly decreased in MI group during the 42 days observation period but decreased at day 1,which was 0.89 ±0.04 of control group in D1,0.25 ±0.03 of control in D14; VEGF-B was significantly suppressed in the infarcted heart,which level was 0.09 ± 0.04 of control; However,VEGF-C and VEGF-D were markedly increased in the infarcted heart in MI group,which was 5.31 ± 0.21 and 9.24 ± 0.47 times of control.Meanwhile,VEGFR-1 and 2 were 0.11 ± 0.02 and 0.14 ± 0.04 of control in the infarcted heart,but VEGFR-3 was significantly increased in blood vessels,6.81 ± 0.42 times of control group.Conclusions VEGF isoforms and VEGFR subtypes were differentially expressed in the infarcted heart.It suggests that these isoforms may regulate multiple responses during cardiac repair/remodeling.
