Diagnostic value of CEA, CA125, CYFRA21-1, and NSE in lung cancer
10.3760/cma.j.issn.1008-1372.2013.02.007
- VernacularTitle:CEA、CA125、CYFRA21-1和NSE在肺癌中的诊断价值
- Author:
Caihua YU
;
Zhihong MA
;
Hongwei LI
;
Qibin SHEN
;
Shuyi FEI
;
Yaping LIU
- Publication Type:Journal Article
- Keywords:
Carcinoembryonic antigen/blood;
CA-125 antigen/blood;
Phosphopyruvate hydratase/blood;
Lung neoplasms/diagnosis;
Antigens,neoplasm/blood;
Tumor markers,biological/analysis
- From:
Journal of Chinese Physician
2013;(2):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of four tumor markers analyzed with Logistic regression and receiver operator characteristic (ROC) curve in patients with lung cancer.Methods The serum levels of carcinoembryonic antigen (CEA) 、carbohydrate antigen 125 (CA125),cytokeratin 19 fragment (CYFRA21-1) and neuron specific enolase (NSE) were determined by radioimmunoassay in 112 patients with lung cancer and 74 patients with benign pulmonary disease.Four tumor markers were analyzed by Logistic regression and ROC curve.Results The serum levels of CEA,CA125,CYFRA21-1 and NSE in lung cancer patients were [4.53(2.22-11.53)ng/ml,28.97 (11.39-62.10) U/ml,4.05(2.29-8.18)ng/ml,14.11 (11.35-24.12) ng/ml],respectively,which were significantly higher than those in health adults[2.08 (1.45-2.52) ng/ml,12.90 (9.80-19.44) U/ml,1.53 (1.21-2.17) ng/ml,11.38 (9.07-12.80) ng/ml] (all P ＜ 0.01).According to regression equation Y =1/[1 + EXP (4.902-0.394X1-0.627X2-0.165X3)],the area under the ROC curve (AUC),sensitivity,specificity,and accuracy of new variable Y were 0.915 ± 0.020,79.46％,93.24％,and 84.95％,respectively.Conclusions Application of logistic regression and ROC curve increases diagnostic accuracy in lung cancer.
