Expressions and clinical significance of VEGFR-1 and VEGFR-2 in preeclampsia
10.3760/cma.j.issn.1008-1372.2013.01.017
- VernacularTitle:血管内皮生长因子受体-1和血管内皮生长因子受体-2在子(癎)前期中的表达及临床意义
- Author:
Hongwei ZENG
;
Xiaoye LI
;
Linfang QIN
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor receptor-1/blood;
Vascular endothelial growth factor receptor-2/blood;
Vascular endothelial growth factor receptor-1/biosynthesis;
Vascular endothelial growth factor receptor-2/biosynthesis;
Pre-eclampsia/blood;
Pre-ecl
- From:
Journal of Chinese Physician
2013;(1):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze tissue vascular endothelial growth factor receptor 1 (VEGFR-1)and VEGFR-2 and their soluble form (sVEFGR-1 and sVEGFR-2) in the plasma in patients with preeclampsia,and to explore its clinical significance.Methods sVEGFR-1 and sVEGFR-2 expressions in plasma of normal pregnancy women and preeclampsia patients were detected by enzyme-linked immunosorbnent assay (ELISA) ; VEGFR-1,VEGFR-2,sVEGFR-1 and sVEGFR-2 mRNA expressions of normal pregnancy women and preeclampsia patients in placenta were detected by reverse transcription-polymerase chain reaction (RT-PCR).Results ELISA results showed that the level of sVEGFR-1 in plasma of normal control group before and after delivery was (12.33 ± 1.52) ng/ml and (4.55 ± 0.31) ng/ml,respectively,while that of preeclampsia group was (77.25 ± 9.47) ng/ml and (8.13 ± 0.74) ng/ml,respectively; the differences between before and after delivery in the two groups were of statistical significance.The level of sVEGFR 2 in plasma of normal control group before and after delivery was (8.74 ± 1.24) ng/ml and (6.43± 0.55) ng/ml,respectively,while that of preeclampsia group was (5.69 ± 0.75) ng/ml and (4.96 ±0.67) ng/ml,respectively.RT-PCR results were consistent with ELISA results.Conclusions Rapid decrease of plasma sVEGFR-1 and continuously low-level expression of plasma sVEGFR-2 indicated that VEGFR-1 might be closely related to preeclampsia,and decrease of plasma sVEGFR-2 in preeclampsia women might be taken as a marker of endothelial cell function disorder.
